منابع مشابه
Anticoagulation interruptus: not without risk.
The need to withhold anticoagulation in patients requiring elective surgery poses a particularly important challenge when the risk of thrombosis and thromboembolism is high. In spite of the increasing use of prosthetic heart valves and the increasing prevalence of atrial fibrillation in the aging population, Kovacs et al1 make the important point in this issue of Circulation that there is a pau...
متن کاملGenetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila.
Hedgehog (Hh) activates a signal transduction pathway regulating Cubitus interruptus (Ci). In the absence of Hh, full-length Ci (Ci-155) is bound in a complex that includes Costal2 (Cos2) and Fused (Fu). Ci-155 is phosphorylated by protein kinase A (PKA), inducing proteolysis to Ci-75, a transcriptional repressor. Hh signaling blocks proteolysis and produces an activated Ci-155 transcriptional ...
متن کاملRoadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.
The final step in Hedgehog (Hh) signal transduction is post-translational regulation of the transcription factor, Cubitus interruptus (Ci). Ci resides in the cytoplasm in a latent form, where Hh regulates its processing into a transcriptional repressor or its nuclear access as a transcriptional activator. Levels of latent Ci are controlled by degradation, with different pathways activated in re...
متن کاملCoitus Interruptus: Are there spermatozoa in the pre-ejaculate?
Coitus interruptus, also known as the withdrawal method, is the oldest form of male contraceptive method to be practiced. [1] It involves the male partner pulling out the penis before ejaculation. [1] Even though it is the oldest method of male contraception to be practiced, research has given it very little attention. The few studies that have been conducted suggest that it is widely practiced...
متن کاملCubitus interruptus-independent transduction of the Hedgehog signal in Drosophila.
The Hedgehog (Hh) family of secreted proteins are key factors that control pattern formation in invertebrates and vertebrates. The manner in which Hh molecules regulate a target cell remains poorly understood. In the Drosophila embryo, Hh is produced in identical stripes of cells in the posterior compartment of each segment. From these cells a Hh signal acts in both anterior and posterior direc...
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ژورنال
عنوان ژورنال: RUS (São Paulo)
سال: 2021
ISSN: 2317-4765
DOI: 10.11606/issn.2317-4765.rus.2021.182823